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KMID : 1123920070210030688
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.688 ~ p.699
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Effects of Sesim-tang Hot Water Extract & Ultra-fine Powder on the Alzheimer’s Disease Model
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Kim Hyun-Soo
Lee Sang-Ryong
Jung In-Chul
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Abstract
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This experiment was designed to investigate the effect of the SST hot water extract & ultra-fine Powder on Alzheimer’s Disease Model Induced by A. The effects of the SST hot water extract on expression of IL-1, IL-6, TNF-, NOS-II, COX-2 mRNA and production of IL-l, IL-6, TNF-, NO in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the SST hot water extract & ultra-fine powder on (1) the behavior (2) expression of IL-1, TNF-, MDA, (3) Glucose, AChE in serum (4) the infarction area of the hippocampus, and brain tissue injury in Alzheimer’s diseased mice induced with A were investigated. The SST hot water extract suppressed the expression of IL-1, IL-6 and TNF-a mRNA in BV2 microglia cell line treated with LPS. The SST hot water extract suppressed the production of IL-1, IL-6, TNF-, NO in BV2 microglial cell line treated with LPS. The SST hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by A in the Morris water maze experiment, which measured stop-through latency. The SST ultra-fine powder suppressed the expression of TNF-a protein significantly in the microglial cell of mice with Alzheimer’s disease induced by A. The SST hot water extract & ultra-fine powder reduced the MDA and suppressed the over-expression of CD68, CD11b in the mice with Alzheimer’s disease induced by A. The SST hot water extract & ultra-fine powder decreased AChE significantly in the serum of the mice with Alzheimer’s disease induced by A. The SST hot water extract & ultra-fine powder reduced infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by A. The SST hot water extract & ultra-fine powder reduced the tau protein, GFAP, and presenilin1, 2 of hippocampus in the mice with Alzheimer’s disease induced by A. These results suggest that the SST hot water extract & ultra-fine powder may be effective for the prevention and treatment of A1zheimer’s disease. Investigation into the clinical use of the SST hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, Sesim-tang(SST), hot water extract & ultra-fine powder
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FullTexts / Linksout information
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